Genetic markers of the proliferative syndrome in age-related macular degeneration and chronic angle-closure glaucoma

Purpose : clinical and genetic research of primary chronic angle-closure glaucoma (PACG) age-related macular degeneration (AMD) for prospective pathogenetically-oriented targeted treatment these condition. Materials methods . 15 patients with isolated ocular proliferative syndrome were divided into 2 groups depending on their diagnosis: 1) 7 (14 eyes) aged 55 to 83 confirmed wet AMD (4 women 3 men). 2) 8 (16 45 80 PACG (5 The followed up 1 years. Results In both conditions, we found mutations in the genes Russian population involved process proliferation: VEGF A, CFH, COL11A1. We developed an algorithm bioinformatic analysis full-exome/full-genome sequencing data which takes account aggregate helps refine prognosis course proliferation. Genetic markers remain unchanged throughout patient’s life, so it is important conduct studies old age. Conclusion To prevent AMD, develop individual pathogenetic therapy schemes diseases, specialized molecular tests are needed, results could be analyzed algorithm.